Table 2.
Coagulation and Blood Product Requirement Characteristics*
| Variable | All (n=35 ECMO runs) | Age ≤30 days (n=21 ECMO runs) | Age >30 days (n=14 ECMO runs) | p-value |
|---|---|---|---|---|
| Heparin (U/kg/h) | 34 (22–48) | 35 (25–47) | 25 (18–52) | <0.001 |
| ACT (s) | 210 (195–227) | 213 (198–228) | 203 (190–221) | <0.001 |
| PT (s) | 11.9 (11.1–13.6) | 12 (11.3–13.6) | 11.3 (10.7–13.7) | <0.001 |
| aPTT (s) | 91.5 (66.4–128.3) | 92.7 (67.5–126.8) | 87.1 (64.1–131.4) | 0.604 |
| Fibrinogen (mg/dL) | 287 (214–365) | 263 (211–345) | 336 (218–472) | <0.001 |
| d-dimer (mg/L) | 6.7 (3.4–14.1) | 7.1 (3.6–14.7) | 6.2 (2.6–12.4) | 0.013 |
| Anti-factor Xa (IU/mL) | 0.4 (0.2–0.6) | 0.35 (0.2–0.5) | 0.5 (0.35–0.7) | <0.001 |
| AT (%) | 60 (48–72) | 57 (47–71) | 64 (55–76) | 0.007 |
| Factor VIII (%) | 67 (38–94) | 58 (34–79) | 114 (83–145) | <0.001 |
| Platelet count (K/mm3) | 113 (96–131) | 116 (102–134) | 102 (83–121) | <0.001 |
| Hemoglobin (g/dL) | 12.5 (12.0–13.2) | 12.6 (12.1–13.2) | 12.3 (11.6–13.3) | <0.001 |
| PRBC (mL/kg/day) | 28 (15–57) | 29 (15–61) | 24 (12–45) | <0.001 |
| Platelets (mL/kg/day) | 29 (16–58) | 33 (18–63) | 18 (12–44) | <0.001 |
| FFP (mL/kg/day) | 0 (0–16) | 0 (0–17) | 0 (0–15) | <0.001 |
| Cryoprecipitate (mL/kg/day) | 0 (0–1.4) | 0 (range 0–30) | 0 (range 0–12) | <0.001 |
ACT, activated clotting time; aPTT, activated partial thromboplastin time; AT, antithrombin III; ECMO, extracorporeal membrane oxygenation; FFP, fresh frozen plasma; PRBC, packed red blood cells; PT, prothrombin time.
*
Data are presented as median (interquartile range) for each group of patients after the median value for each variable was calculated longitudinally for each patient.
*
Data are presented as median (interquartile range) for each group of patients after the median value for each variable was calculated longitudinally for each patient.