Fig. 7.

Late neutralization of periostin function improves survival and fibrosis. Wild-type mice were injected with 0.05 U of bleomycin on day 0. On days 10 and 15, mice were injected intraperitoneally with 200 μg of OC-20 Ab or 200 μg of irrelevant Ab control. A: survival was monitored over a 19-day period (n = 10 mice/group). B: lungs were collected for histology, representative of 2 experiments. C: mice were injected with 0.025 U of bleomycin (Bleo) prior to treatment with OC-20 or control Ab as described above, and lungs were harvested for hydroxyproline analysis on day 21 (n = 8–11/group combined from 2 separate experiments).