Table 1.
Top 10 human tissues with robust δ ENaC (SCNN1D) expression profiles
| Gene (Median) | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
|---|---|---|---|---|---|---|---|---|---|---|
| SCNN1Da | Testis | Ovary | Pancreas | Brain | Heart | Thymus | Skeletal muscle | Liver | Lung | Blood leukocytes |
| SCNN1Db | Heart | Kidney | Liver | Brain | Pancreas, Fetal Kidney | Placenta, Stomach | Trachea, Fetal heart, Bone marrow | Adrenal gland | Transverse colon, Duodenum, Jejunum | Spleen, Fetal lung, Fetal brain |
| SCNN1D (4.3)c | Liver (7.1) | Heart (7.1) | Thyroid (6.5) | CD34+ (6.5) | Skeletal muscle (6.5) | Prefront cortex (6.15) | Retina, Prostate, Ganglionf (6.1) | Pituitary (5.9) | Smooth muscle (5.65) | Lung, Whole blood (5.5) |
| SCNN1Ad (5.3) | Lung (733) | Kidney (492) | Thyroid (444) | Trachea (347) | Colon (290) | Prostate (245) | Salivary gland (135) | Tongue (108) | Pancreatic islet (102) | Retina (71) |
| SCNN1Be (4) | Lung (150) | Tongue (30) | Placenta (26) | Skin (10) | Kidney (9) | Thyroid (8) | Salivary gland (6) | Globus pallidus (5.4) | Bone marrow (5.3) | Heart, Liver, Lymphocyte, DRG (5) |
| SCNN1G (5.1) | Liver (4.5) | Heart (4.35) | Prefron-tal (4.35) | CD34+ (4.3) | Thyroid (4.3) | Skeletal muscle (4.15) | Prostate (4.1) | Retina (4.18) | Pituitary (4.0) | Smooth muscle (3.9) |
Normalized expression levels are in parentheses. ENaC, epithelial sodium channel. aData are adapted from Waldmann et al. (134): Northern blot with mRNA samples for 16 types of tissues (5.5 kDa). bData are adapted from Yamamura et al. (148): Dot-blot with 73 human samples for 73 types of tissue/organ. cAdapted from BioGPS (http://biogps.org/#goto=welcome) (142). The microarray database “GeneAtlas U133A, gcmas” was produced by an Affymetrix U133A array with data processed by the gcrma algorithm. Data were statistically analyzed for 176 human samples for 84 types of tissue/organs (124). dCCIB rank: 1 kidney, 2 conjunctiva, 3 trachea/lung, 4 stomach/esophagus, 5 thyroid /ES cell, 6 salivary gland, 7 breast, 8 prostate, 9 tongue, 10 skin. eCCIB rank: 1 esophagus, 2 tongue, 3 lung, 4 kidney, 5 placenta, 6 skin, 7 stomach, 8 salivary gland, 9 colon, 10 globus pallidus/Treg/superior cervical ganglion. fSuperior cervical ganglion (6.35) and trigeminal ganglion (5.85).