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. 2012 Oct 31;303(12):R1261–R1267. doi: 10.1152/ajpregu.00457.2012

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Copyright © 2012 the American Physiological Society

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Fig. 1. — Phosphorylation of insulin receptor substrate (IR)^Tyr1162/1163 (A), IRS1^{pan Tyr} (B), IRS^Ser312 (C), IRS1-associated phosphatidylinositol 3-kinase (PI3K) activity (D), and phosphorylation phosphatase and tension homologue (PTEN)^Ser380 (E). CR, calorie-restricted group; AL, ad libitum food consumption group. Main effects of diet, insulin, and diet × insulin interactions are reported from two-way ANOVA analysis. P ≤ 0.05 is considered statistically significant. Values are means ± SE; n = 7–18 per treatment group.