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General synthesis scheme of piperidyl benzamides reverse amides, sulfonamides and ureas. Reagents and conditions: (a) (i) DPPA, Et3N, t-BuOH, reflux; (ii) TFA, DCM, 23 °C, 33%; (b) R′CO2H, HATU, DIEA, DMF, 23 °C; or R′SO2Cl, DIEA, CH2Cl2; or R′NCO, toluene, 80 °C, 40–80%.
