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. 2009 Dec 15;19(24):6970–6974. doi: 10.1016/j.bmcl.2009.10.050

Table 2.

Piperidyl benzamides SAR: linker modifications

graphic file with name fx13.jpg

Compds R P. falciparum 3D7 strain EC50, μMa
14 graphic file with name fx14.gif 0.201
15 graphic file with name fx15.gif 0.402
16 graphic file with name fx16.gif 8.25
17 graphic file with name fx17.gif 4.68
18 graphic file with name fx18.gif 0.452
19 graphic file with name fx19.gif 0.328
20 graphic file with name fx20.gif 1.98
21 graphic file with name fx21.gif 0.638
22 graphic file with name fx22.gif 0.734
23 graphic file with name fx23.gif 0.423
a

Values are means of two experiments. Each assay plate has mefloquine, sulfadoxine and artimesinin as internal standards. The EC50 values for standard compounds match the literature values.