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. 2009 Dec 15;19(24):6970–6974. doi: 10.1016/j.bmcl.2009.10.050

Table 3.

Piperidyl benzamides SAR: center ring modifications

graphic file with name fx24.jpg

Compds X P. falciparum 3D7 strain EC50, μMa
24 graphic file with name fx25.gif 0.766
25 graphic file with name fx26.gif 5.88
26 graphic file with name fx27.gif 0.674
27 graphic file with name fx28.gif 1.67
28 graphic file with name fx29.gif 2.98
29 graphic file with name fx30.gif 2.08
a

Values are means of two experiments. Each assay plate has mefloquine, sulfadoxine and artimesinin as internal standards. The EC50 values for standard compounds match the literature values.