Table 4.
The 5-Gene Molecular Signature: Univariate Predictors
| Variable | 5-Gene Molecular Signature | ||||
|---|---|---|---|---|---|
| Baseline Variable | No. of Patients | HR | P | Adjusted HR | P |
| Race (Caucasian vs non-Caucasian; effect of Caucasian) | 257 | 4.063 | .018 | 1.607 | .035 |
| Bowel obstruction/perforation (positive vs negative) | 232 | 4.016 | <.001 | 1.656 | .027 |
| Perineural invasion (positive vs negative) | 123 | 2.432 | .021 | 1.377 | .405 |
| Lymphovascular invasion (positive vs negative) | 254 | 2.023 | .001 | 1.848 | .010 |
| Adenocarcinoma subtype (mucinous vs nonmucinous; effect of nonmucinous) | 264 | 1.749 | .156 | 1.839 | .006 |
| Histologic grade (continuous) | 262 | 1.354 | .131 | 1.859 | .006 |
| Sex (man/woman; effect of woman) | 264 | 1.315 | .203 | 1.772 | .010 |
| Right-sided vs left-sided tumor (effect of left-sided tumor) | 261 | 1.202 | .385 | 1.695 | .019 |
| T-classification (continuous) | 264 | 1.106 | .511 | 1.720 | .019 |
| No. lymph nodes examined (continuous) | 264 | 0.997 | .836 | 1.786 | .010 |
| Age at surgery (continuous) | 264 | 0.994 | .534 | 1.772 | .011 |
Abbreviations: HR, hazard ratio.