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. 2010 Apr 2;114(1):130–141. doi: 10.1111/j.1471-4159.2010.06728.x

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© 2010 The Authors. Journal Compilation © 2010 International Society for Neurochemistry

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Ketones mitigate synaptic suppression induced by the mitochondrial complex II inhibitor [3-nitropropionic acid (3-NP)]. (a) Either 1 mmol/L (•) or 10 mmol/L () irreversibly suppressed the PS amplitude in CA1 hippocampus. Pre-treatment with ketones did not produce a synaptic protective effect against 10 mmol/L 3-NP (), whereas ketones significantly reduced PS suppression induced by 1 mmol/L 3-NP (), and then restored the PS amplitude to basal levels after a 20-min washout. Lower concentrations of ketones (0.5 mmol/L each) were partially protective (). (b) During the initial period of 1 mmol/L 3-NP treatment (○), the mean field potential amplitude was slightly increased. After 30 min, the field potential showed dramatic decay and then did not change during wash-out. While pre-treatment with ketones slowly decreased the field potential amplitude compared to 1 mmol/L 3-NP alone, no beneficial effect occurred after 60 min of co-application. However, ketones significantly enhanced the recovery of the field potential amplitude after wash-out.

Inline graphic — Ketones mitigate synaptic suppression induced by the mitochondrial complex II inhibitor [3-nitropropionic acid (3-NP)]. (a) Either 1 mmol/L (•) or 10 mmol/L () irreversibly suppressed the PS amplitude in CA1 hippocampus. Pre-treatment with ketones did not produce a synaptic protective effect against 10 mmol/L 3-NP (), whereas ketones significantly reduced PS suppression induced by 1 mmol/L 3-NP (), and then restored the PS amplitude to basal levels after a 20-min washout. Lower concentrations of ketones (0.5 mmol/L each) were partially protective (). (b) During the initial period of 1 mmol/L 3-NP treatment (○), the mean field potential amplitude was slightly increased. After 30 min, the field potential showed dramatic decay and then did not change during wash-out. While pre-treatment with ketones slowly decreased the field potential amplitude compared to 1 mmol/L 3-NP alone, no beneficial effect occurred after 60 min of co-application. However, ketones significantly enhanced the recovery of the field potential amplitude after wash-out.