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. 2010 Apr 2;114(1):130–141. doi: 10.1111/j.1471-4159.2010.06728.x

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© 2010 The Authors. Journal Compilation © 2010 International Society for Neurochemistry

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Effects of antioxidants on hippocampal synaptic suppression by mitochondrial respiratory complex (MRC) inhibitors. (a) Neither 600 U/mL catalase (•) nor 200 μmol/L MnTBAP (○) blocked the synaptic suppression caused by 100 nmol/L Rot. Pre-treatment with cell-permeable 500 μmol/L GSHMEE () alone also had no effect on Rot-induced PS suppression. (b) Co-application of a cocktail of 600 U/mL catalase and 200 μmol/L MnTBAP with 1 mmol/L 3-NP resulted in recovery of the PS amplitude. Similarly, pre-treatment with GSHMEE also restored the PS amplitude against 3-NP application.

Inline graphic — Effects of antioxidants on hippocampal synaptic suppression by mitochondrial respiratory complex (MRC) inhibitors. (a) Neither 600 U/mL catalase (•) nor 200 μmol/L MnTBAP (○) blocked the synaptic suppression caused by 100 nmol/L Rot. Pre-treatment with cell-permeable 500 μmol/L GSHMEE () alone also had no effect on Rot-induced PS suppression. (b) Co-application of a cocktail of 600 U/mL catalase and 200 μmol/L MnTBAP with 1 mmol/L 3-NP resulted in recovery of the PS amplitude. Similarly, pre-treatment with GSHMEE also restored the PS amplitude against 3-NP application.