Table 2.

Risk and Ancestry Summary^a

Elective Group	Tests	Pos Rate	Seq Positive	LR Positive	Seq Pos Rate	LR Pos Rate	Seq % of Positives	LR % of Positives	BART %: LRP %
African	947	11.5%	108	1	11.4%	0.1%	99.1%	0.9%	100%:0%
Ashkenazi	250	11.2%	28	0	11.2%	0.0%	100.0%	0.0%	n/a
Asian	661	6.8%	43	2	6.5%	0.3%	95.6%	4.4%	100%:0%
Central/Eastern Europe	971	8.5%	79	4	8.1%	0.4%	95.2%	4.8%	75%:25%
Latin American/Caribbean	830	11.4%	80	15	9.6%	1.8%	84.2%	15.8%b	93%:7%
Native American	74	5.4%	4	0	5.4%	0.0%	100.0%	0.0%	n/a
Near East/Mideast	178	9.6%	17	0	9.6%	0.0%	100.0%	0.0%	n/a
None specified only	2772	9.2%	232	22	8.4%	0.8%	91.3%	8.7%	73%:27%
Western/Northern Europe	13,644	7.5%	961	60	7.0%	0.4%	94.1%	5.9%	67%:33%
High-Risk Group	Tests	Pos Rate	Seq Positive	LR Positive	Seq Pos Rate	LR Pos Rate	Seq % of Positives	LR % of Positives	BART %: LRP %
African	1767	29.4%	476	43	26.9%	2.4%	91.7%	8.3%	98%:2%
Ashkenazi	676	12.7%	82	4	12.1%	0.6%	95.3%	4.7%	75%:25%
Asian	552	23.9%	125	7	22.6%	1.3%	94.7%	5.3%	100%:0%
Central/Eastern Europe	1716	24.5%	386	34	22.5%	2.0%	91.9%	8.1%	71%:29%
Latin American/Caribbean	1560	31.2%	383	104	24.6%	6.7%	78.6%	21.4%b	99%:1%
Native American	285	17.9%	49	2	17.2%	0.7%	96.1%	3.9%	100%:0%
Near East/Mideast	195	24.6%	40	8	20.5%	4.1%	83.3%	16.7%c	100%:0%
None specified only	3831	23.6%	827	78	21.6%	2.0%	91.4%	8.6%	72%:28%
Western/Northern Europe	12,229	23.1%	2552	271	20.9%	2.2%	90.4%	9.6%	64%:36%

BART indicates BRACAnalysis Rearrangement Test; LR, large rearrangement; LRP, Large Rearrangement Panel; n/a, not applicable; Pos, positive; Seq, sequence.

^aThe mutation profile of BRCA1 and BRCA2 sequencing and LR mutations between the high-risk and elective groups are broken down by reported ancestry. Patients reporting multiple ancestries were excluded from this portion of the analysis. Ashkenazi Jewish patients only included those who underwent testing beyond the 3 most common Ashkenazi founder mutations.

^bP < .001, Fisher's exact test.

^cP = .15, Fisher's exact test.