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TRAP staining after osteoclast induction for 7 days. RANKL and M-CSF induced a large number of osteoclasts, while effectively inhibiting osteoclastogenesis (×10). a Control. b, c, d, e Naringin at 1, 10, 50, and 100 μg/mL, respectively. f The PMMA particles used in this research. g Large number of osteoclast formed after osteoclastogenic induction. Naringin effectively suppressed osteoclastogenesis. * Significant difference compared with the control (P < 0.05, n = 6)
