Figure 5.

Anti-tumor efficacy of the NIR-responsive NP platform on HeLa-Luc tumor-bearing mice. ONT-NR, T-DNA-NR, and T-DNA(Dox)-NR were injected intratumorally in a single dose (4.5×10¹⁰ NR particles), followed by 10 min of NIR irradiation or without NIR irradiation. Images were taken at day 0, 1, 3, 5, 8, 10, and 12, respectively. The changes in luminescence intensity indicate the tumor growth. a) Representative mice images showing the tumor progression under different treatment conidtions. b) The tumor luciferase intensities relative to day 0 are plotted over time after NIR irradiation. Data are presented as mean±SE of seven mice per group. *,P<0.05 by two-sample student’s t-test.