Figure 7.

Reduced KC frequency limits liver injury mediated by ischemia reperfusion after cold storage and transplantation. A: After 24 hours of cold preservation and 6 hours after reperfusion after orthotopic liver transplantation, AVMN mice (n = 5) had significantly lower alanine aminotransferase (P = < 0.001) and aspartate aminotransferase (P = 0.003) levels compared with CL mice (n = 5). B: Liver histologic analysis confirmed noticeably less injury in the AVMN mice that harbor significantly fewer KCs. The foci of coagulative-type necrosis were irregularly shaped and more often located in perivenular regions (arrows). *P < 0.001, **P < 0.01.