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. Author manuscript; available in PMC: 2012 Dec 29.
Published in final edited form as: Expert Opin Investig Drugs. 2010 Feb;19(2):235–242. doi: 10.1517/13543780903563364

Fig 2. Proteasome inhibitors stabilize hypothetical negative regulator of FOXM1 (NRFM) that inhibits transcriptional activity of FOXM1 and its expression because of positive autoregulation of FOXM1.

Fig 2

(A) Untreated cells where FOXM1 transcriptional activity is required for its expression (B) Cells treated with proteasome inhibitor, which stabilizes NRFM leading to suppression of F OXM1 transcriptional activity and expression.