Env-specific binding antibody profiles by peptide arrays. Sera from baseline and week 28 were assessed using peptide arrays (JPT Peptide Technologies) to assess linear antibody responses to peptides spanning Env from clades M, A, B, C, D, CRF02, and CRF01. Mean signal intensity (week 28 with baselines subtracted) from all subjects in each group is depicted. Black asterisks denote peptides with significantly elevated mean signal intensity as compared with placebos (P < .05, by Wilcoxon Mann–Whitney U tests), and red asterisks denote trends (P < .10).