Figure 2.

Env-specific functional nonneutralizing antibody binding responses and antibody isotypes. A, Serum from multiple time points from subjects who received 10⁹ viral particles (vp), 10¹⁰ vp, and 10¹¹ vp of the vaccine were assessed for antibody-dependent cellular phagocytosis (ADCP), cellular inhibition (ADCVI), and macrophage inflammatory protein 1β degranulation. Bars represent mean responses. B, Percentage of vaccinees in these groups at week 8 and week 28 that exhibit multiple antibody functions (ADCP/ADCVI/degranulation). C, Immunoglobulin G (IgG) isotypes of Env gp140-, gp120-, and gp41-specific binding antibodies from week 8 and week 28 from subjects who received 10⁹ vp, 10¹⁰ vp, and 10¹¹ vp of the vaccine are shown in pie charts. Mean proportional IgG1, IgG2, IgG3, and IgG4 responses are shown for each group.