Figure 5.

The 2D v_e/K^trans parameter spaces showing 400 Monte Carlo SSM(FXR-a) [Eq. (5), ${{\mathrm{R}}_{2\mathrm{S}}}^{\ast }\to \infty ,{{\mathrm{R}}_{2\mathrm{L}}}^{\ast }\to 0$] fittings (points) and SM(FXL-c) [Eqs. (1)-(4), τ_b = τ_i → 0] fittings (points) of the three Fig. 1d-f time-course points: suspicious (a), NAG (b), and muscle (c). The Δ biomarkers, Δv_e and ΔK^trans, are defined in panel a. It is seen that ΔK^trans is significantly large for only the suspicious ROI: malignancy was subsequently found on the same side of the prostate as this ROI.