Table 2.
Antifungal activity (MIC and MBC) of the essential oil of Mentha piperita against standard and clinical isolates of yeasts.
| Mentha piperita essential oil | |||
|---|---|---|---|
| Strain (number of isolate) | MIC (μL/mL) | MFC (μL/mL) | |
| GMa (range) | GMa (range) | ||
| Standard isolate | C. albicans (6) | 1.5 (1-2) | 3.3 (2–4) |
| C. glabrata (5) | 1.2 (0.5–2) | 2.8 (2–4) | |
| C. tropicalis (1) | 1.0 | 2.0 | |
| C. krusei (1) | 0.5 | 1.0 | |
| C. dubliniensis (5) | 2.4 (2–4) | 6.0 (4–8) | |
| C. parapsilosis (1) | 4.0 | 4.0 | |
| C. neoformance (1) | 4.0 | 4.0 | |
|
| |||
| Azole-sensitive clinical isolates | C. albicans (9) | 2.0 (0.12–4) | 2.8 (2–4) |
| C. dubliniensis (3) | 0.6 (0.5–1) | 1.6 (1-2) | |
| C. tropicalis (2) | 2.0 | 2.0 | |
| C. parapsilosis (3) | 1.1 (0.5–2) | 4.0 | |
| C. glabrata (1) | 0.12 | 4.0 | |
|
| |||
| Azole-resistant clinical isolates | C. albicans (12) | 1.6 (1-2) | 2.3 (1–4) |
| C. dubliniensis (2) | 0.5 | 2.5 (1–4) | |
| C. tropicalis (3) | 3.0 (2–4) | 3.0 (2–4) | |
aGeometric mean; MIC: minimum inhibitory concentration; MFC: minimum fungicidal concentration.