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. 2012 Dec 13;2012:147863. doi: 10.1155/2012/147863

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Copyright © 2012 Kunal Sonavane et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Curcumin's effects on AKT/MTOR and ERK pathways in vitro. (a) Western blot of SRB12-p9 tumor cells treated with (+) or without (−) 20 μM curcumin for 24 hours and probed with the indicated antibody. Representative Western blots for two analyzed sets are shown. (b) Band densities of indicated biomarkers (n = 6) were quantified using ImageQuant software and normalized to actin protein level. Data presented as Mean ± SE. * Indicates P < 0.05 versus vehicle-treated control. A significant inhibition of expression of the following biomarkers was observed: pAKT (P = 0.0368); pS6 (P = 0.0182); p4EBP1 (P = 0.0098); pSTAT3 (P < 0.0001); pERK1/2 (P = 0.0313). a.u.: arbitrary units.