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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Psychoneuroendocrinology. 2012 Aug 19;38(4):509–521. doi: 10.1016/j.psyneuen.2012.07.011

Figure 6.

Figure 6

Decreased transcription factors (TFs) for GABAergic migration due to PS. NS and PS offspring did not differ in TFs determining dorsal-ventral fate (A, B) at E13. Variable decreases in expression with PS without changes in localization was shown at E13 for TFs involved in GABAergic progenitor migration, dlx1 (C), dlx2 (D), and nkx2.1 (E). Quantification of gene expression changes with PS in the ventral telencephalon by qPCR in basal ganglia for these TFs demonstrated that dlx1 showed no consistent alteration at E13 (F, left) but dlx2 (F, right), nkx2.1 (G, left), and their downstream target erbb4 (G, right) were decreased at all embryonic time points. Quantification of gene expression in dorsal telencephalon for bdnf and fgf2 showed no significant changes with PS (H) (* indicates p<0.05 for main effect of condition by one-way ANOVA, *^ indicates p<0.05 for interaction of condition by age by two-way ANOVA). Scale bar=200 µm.