Table 3.
Therapeutic area | Licensing status | Immediate postpolicy absolute change in % market share (95% CI) |
---|---|---|
Diabetes | ||
Antidiabetics | Originator brand | −0.3% (−1.6 to 1.0) |
Branded generic | −12.3% (−16.0 to −8.7)* | |
Generic | −3.5% (−5.8 to −1.1)* | |
GPO | 16.1% (12.0 to 20.2)* | |
Insulins‡ | Originator brand† | −0.04% (−0.4 to 0.3) |
Branded generic | 7.0% (2.9 to 11.1)* | |
Generic | −6.2% (−10.3 to −2.1)* | |
Cardiovascular disease | ||
Antihypertensives | Originator brand† | −0.1% (−2.3 to 2.0) |
Branded generic† | −0.2% (−6.1 to 1.8) | |
Generic | −5.7% (−8.3 to −3.0)* | |
GPO | 5.3% (−0.1 to 10.6) | |
Lipid regulating agents | Originator brand† | −7.8% (−10.2 to −5.4)* |
Branded generic† | 7.6% (5.1 to 10.0)* | |
Generic | 0.2% (−0.4 to 0.7) | |
GPO | 0.2% (−0.3 to 0.8) | |
Cardiac therapy | Originator brand | 0.1% (−0.8 to 1.0) |
Branded generic† | −13.5% (−20.5 to −6.5)* | |
Generic | −4.3% (−6.2 to −2.4)* | |
GPO | 21.6% (15.0 to 28.1)* | |
Cancer‡ | ||
Antineoplastics | Originator brand | 1.1% (−1.0 to 3.2) |
Branded generic | −1.0% (−5.4 to 3.4) | |
Generic | 0.4% (−2.7 to 3.4) | |
Cytostatic hormones | Originator brand† | 0.4% (−5.4 to 6.1) |
Branded generic† | −7.7% (−12.0 to −3.5)* | |
Generic† | 6.0% (1.4 to 10.6)* | |
Immunostimulating agents | Originator brand | −6.4% (−9.7 to −3.0)* |
Branded generic | 4.5% (1.7 to 7.3)* | |
Generic | −0.2% (−0.3 to 0.02) |
*Statistically significant regression coefficient (p<0.05). Changes are in absolute terms (ie, percentage point change).
†Quadratic model (which has a squared postpolicy trend term) fits better than linear model.
‡GPO did not produce any insulins or cancer medicines during the study period.
Note 1: See online appendix table 4 and figures 9–16 for market share regression coefficients and figures for all therapeutic areas.
Note 2: Aside from the immediate level changes following the policy, there were few major changes in market share. See online appendix table 5 for absolute 1- and 5-year differences.