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Increased proteasome activity decreases aggregate burden in disomic strains. Wild-type (WT) (A3369), disome II (A33370), disome V (A33371), and disome IX (A33372) cells harboring a deletion of UBP6 and the HSP104-eGFP fusion were grown to exponential phase in YEPD, and the percentage of cells harboring Hsp104-eGFP foci was determined. n = 3; SEM, n = 100 cells per time point.
