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. 2012 Dec 15;26(24):2802–2816. doi: 10.1101/gad.207142.112

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Copyright © 2012 by Cold Spring Harbor Laboratory Press

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Figure 4. — Functional characterization of Gli1/Sox2-cobound CRMs. Transient transgenic analysis of class II regulatory regions performed at the forelimb level in E10.5 embryos. Numbers in the top right corner of each panel show expressing embryos/total transgenic embryos. (A) Nkx6.2(+54kb). Note Nkx6.2 expression flanked by Dbx1 and Nkx6.1 (Briscoe et al. 2000). (B,C,I,J) Analysis of Nkx6.1(+140kb and +540kb) Gli1-bound regions. (D,K) Characterization of Gli input to Olig2(−33kb). (E,L) Sox-binding sites are required for Nkx2.2(−2kb) enhancer activity. (F,G,H) Foxa2(+6kb, +160kb, and +170kb) enhancer activity. Bar, 50 μm.