Figure 10.

NR2A expression is unaltered in hippocampal slices after the induction L-LTP, and inhibition of NR2A does not rescue L-LTP impairments in the amygdala of Cdh1 cKO mice. (A) (Left) Representative Western blots of Shank1 and NR2A in hippocampal tissue from WT and Cdh1 cKO mice after either no stimulation (control) or four trains of HFS. Actin was used as a loading control. (Right) Quantification of Shank1 and NR2A expression in WT and Cdh1 cKO mice after either no stimulation (control) or four trains of HFS. WT, n = 8 slices; cKO, n = 9 slices. (**) P < 0.01, Student's t-test. (B) L-LTP induced with five trains of HFS is impaired in amygdala slices from Cdh1 cKO mice in control slices and slices treated with 400 nM PEAQX. Control, n = 4 slices; PEAQX, n = 3 slices.