Table 1.
Receptor | Function | Endogenous ligand | Non-self ligand |
---|---|---|---|
KIR2DL1 | Inhibitory | HLA-C (group 2) | |
KIR2DL2 | Inhibitory | HLA-C (group 1, a subset of group 2), some HLA-B | |
KIR2DL3 | Inhibitory | HLA-C (group 1, a subset of group 2), some HLA-B | |
KIR2DL4 | Activating? | HLA-G | |
KIR2DL5 | Inhibitory | ? | |
KIR3DL1 | Inhibitory | HLA-Bw4, a subset of HLA-A | |
KIR3DL2 | Inhibitory | HLA-A3, A11 | CpG ODN |
KIR3DL3 | Inhibitory | ? | |
KIR2DS1 | Activating | HLA-C (group 2) | |
KIR2DS2 | Activating | HLA-C (group 1)? | |
KIR2DS3 | Activating | HLA-C (group 2)? | |
KIR2DS4 | Activating | A subset of HLA-Cw4, A11 | |
KIR2DS5 | Activating | ? | |
KIR3DS1 | Activating | HLA-Bw4, a subset of HLA-A? | |
LILRB1 | Inhibitory | HLA-A, B, C, E, F, G | CMV UL18 |
LILRB2 | Inhibitory | HLA-A, B, C, E, F, G, ANGPTLs (Zheng et al., 2012) | |
LILRB3-5 | Inhibitory | ? | |
LILRA1 | Activating | HLA-B27, HLA-CfHC | |
LILRA2, 4–6 | Activating | ? | |
LILRA3 | Soluble | HLA-CfHC, HLA-A, HLA-G | |
PIR-B | Inhibitory | MHCI (Nakamura et al., 2004) | |
Nogo, MAG, OMgp (Atwal et al., 2008) | |||
ANGPTLs (Zheng et al., 2012) | |||
PIR-A | Activating | MHCI (Nakamura et al., 2004) | |
PILRα | Inhibitory | CD99, PANP, NPDC1, COLEC12 | HSV-1 gB |
PILRβ | Activating | CD99 | HSV-1 gB |
SIRPα | Inhibitory | CD47, SP-A, SP-D | |
SIRPβ | Activating | SP-D | |
SIRPγ | No signal | CD47 | |
DCIR | Inhibitory | ? | |
DCAR | Activating | ? | |
NKRP1-A | Activating | LLT1 | |
NKRP1-D | Inhibitory | Clrb (Iizuka et al., 2003) | |
NKRP1-C, F | Activating | Clrg (Iizuka et al., 2003) | |
Ly49A, C, I, etc | Inhibitory | H-2 | CMV m157 |
Ly49D, H, etc | Activating | CMV m157, others? | |
CD94/NKG2A | Inhibitory | HLA-E (Qa-1) | |
CD94/NKG2C, E | Activating | HLA-E (Qa-1) | Others? |
MAIR-I | Inhibitory | ? | |
MAIR-II | Activating | ? | |
CD200R1 | Inhibitory | CD200 (Wright et al., 2003) | |
CD200R3,4 | Activating | ? |
ANGPTLs, angiopoietin-like proteins; fHC, free heavy chain; Nogo, neurite outgrowth inhibitor; MAG, myelin-associated glycoprotein; OMgp, oligodendrocyte myelin glycoprotein; Clrb, C-type lectin-related molecule b.