Figure 2. Mechanisms of pannexin1 channel modulation.

Schematic outlining direct mechanisms of Panx1 channel modulation including activation via plasma membrane stretch/strain, membrane depolarization, extracellular potassium, low oxygen tension, G protein-coupled receptor, caspase cleavage and ionotropic receptors including P2X. Panx1 can be inhibited directly by high levels of extracellular ATP, and Panx1 channel activity at the level of the plasma membrane can be regulated by trafficking dynamics.