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. 2012 Oct 15;590(Pt 24):6381–6387. doi: 10.1113/jphysiol.2012.237925

Figure 1. β-adrenergic inotropy in skeletal muscle is dependent on phosphorylation of serine 2844 in the RyR1.

Figure 1

A and C, representative twitch force in extensor digitorum longus muscle from (A) wild-type (WT) and (C) S2844A mice. Force was normalized to the maximal twitch force before application of isoproterenol (ISO), which was set to 1. B and D, average specific force (twitch force normalized to cross-sectional area) before and after ISO in (B) WT and (D) S2844A EDL muscles. E, rate of force development before and after ISO in WT and S2844A extensor digitorum longus muscles. All pooled data are presented as mean ± SEM, n= 8 muscles for all groups. *P < 0.05, **P < 0.01 (paired t test for comparisons before and after ISO in the same muscle), ##P < 0.01 (unpaired t test, for comparison of WT and S2844A groups). NS, difference between control and ISO in the S2844A group was not significant (paired t test).