. Author manuscript; available in PMC: 2012 Dec 31.

Published in final edited form as: J Med Chem. 2012 Nov 27;55(23):10674–10684. doi: 10.1021/jm301345v

Table 4.

Uptake (% dose kg/g) of 18-[¹⁸F]fluoro-4-thia-(9Z)-octadec-9-enoic acid (3) in fasted Sprague-Dawley rats

ORGAN/TISSUE (N = 5)	CONTROL 30 MIN^*^¶	POCA TREATED 30 MIN	CONTROL 120 MIN	POCA TREATED 120 MIN^*^¶
Blood	0.0441±0.0121	0.0606±0.0096	0.0185±0.005^**	0.0141±0.0098
Heart	0.7028±0.3019	0.1155±0.0211^£	0.8164±0.2249	0.0760±0.0360
Lung	0.0496±0.0096	0.0458±0.0061	0.0228±0.005^**	0.0179±0.0109
Liver	1.1847±0.1550	0.8162±0.1420^£	0.8488±0.2232^**	0.1666±0.0706^€
Kidney	0.2035±0.0510	0.1932±0.0173	0.1244±0.0310	0.0611±0.0222^€
Brain	0.0206±0.0057	0.0368±0.0044^£	0.0215±0.0051	0.0206±0.009
Bone	0.1531±0.0796	0.1475±0.0355	0.4610±0.4140	0.2990±0.1645
Muscle	0.0201±0.007	0.0297±0.0039^£	0.0171±0.0024	0.0216±0.0137

Pretreated with POCA (30 mg/kg i.p.) 2 hr prior

^¶

ref 10

^£

p=<0.05 for 30 m control vs 30 m POCA

^**

p=<0.05 for 30 m control vs 120 m control

^€

p=<0.05 for 120 m control vs 120 m POCA