. Author manuscript; available in PMC: 2012 Dec 31.

Published in final edited form as: J Med Chem. 2012 Nov 27;55(23):10674–10684. doi: 10.1021/jm301345v

Table 5.

Distribution of ¹⁸F-radioactivity (% of total) in aqueous, organic and pellet fractions after Folch-Type extraction of tissues

Compound		30 min Control	30 min POCA^a	120 min Control	120 min POCA^a
2
Heart (n =6)	Aqueous	2.63±1.00	15.28±3.96^b	4.17±1.31	7.53±2.25^b
	Organic	38.56±19.03	51.90±3.86	18.88±10.79	67.98±6.82^b
	Pellet	58.80±19.21	32.81±6.12^b	76.93±10.77	24.47±5.35^b
Liver (n =6)	Aqueous	13.52±8.30	20.23±4.88	5.32±0.82	11.52±1.13^b
	Organic	48.25±8.35	41.68±6.53	31.39±9.80	50.00±8.31^b
	Pellet	38.21±13.23	38.07±4.09	63.27±9.25	38.47±8.58^b
Muscle (n =6)	Aqueous	23.24±8.37	25.13±2.90	16.17±4.64	19.16±4.09
	Organic	33.56±13.11	42.23±6.23	34.00±12.3	48.14±7.73
	Pellet	43.18±16.90	32.63±5.99	49.81±16.94	32.69±5.13
3
Heart (n =5)	Aqueous	2.86±1.55	10.15±2.55^b	1.86±0.37	4.19±1.04^b
	Organic	8.46±0.86	62.03±7.43^b	9.34±0.42	66.66±11.65^b
	Pellet	88.67±1.63	23.80±5.76^b	88.78±0.71	29.14±10.80^b
Liver (n =5)	Aqueous	8.43±1.10	16.30±3.66^b	5.68±0.19	8.10±2.07
	Organic	19.87±3.32	58.80±4.90^b	34.75±12.14	68.06±3.39^b
	Pellet	71.69±4.34	24.88±3.54^b	59.56±12.02	23.82±3.75^b
Muscle (n=5)	Aqueous	18.79±3.83	24.06±5.81	9.91±2.52	11.37±1.57
	Organic	21.75±4.86	43.19±4.95^b	21.98±4.18	53.25±9.73^b
	Pellet	59.12±8.66	32.74±6.02^b	67.95±1.75	35.36±11.08^b
4
Heart (n =6)	Aqueous	3.97±1.01	7.73±0.62^b	2.39±0.95	3.39±3.17
	Organic	17.29±2.61	67.58±3.94^b	26.14±5.50	74.91±6.52^b
	Pellet	78.72±3.49	24.67±3.92^b	71.45±5.49	21.68±3.63^b
Liver (n =6)	Aqueous	15.36±1.68	31.69±5.95^b	8.18±4.73	10.23±3.80
	Organic	51.66±5.80	51.76±7.03	55.69±8.48	67.69±13.75
	Pellet	32.97±6.71	16.53±1.87^b	36.13±11.75	22.07±13.63
Muscle (n =6)	Aqueous	28.99±3.73	25.80±5.01	11.58±3.65	9.12±2.18
	Organic	38.77±5.36	47.15±2.67^b	48.90±7.54	58.25±8.75
	Pellet	32.22±5.24	27.04±3.35	39.51±4.831	32.62±8.20
5
Heart (n =6)	Aqueous	4.02±1.24	3.84±1.31	4.03±1.42	3.30±1.07
	Organic	25.81±10.12	63.99±9.67^b	28.56±6.62	74.20±7.78^b
	Pellet	70.16±9.05	32.16±10.47^b	67.39±6.01	22.48±6.91^b
Liver (n =6)	Aqueous	9.65±3.27	10.75±2.01	10.15±4.50	7.45±2.00
	Organic	45.61±5.10	54.88±6.96	35.26±4.02	64.78±10.98^b
	Pellet	44.72±4.54	34.35±7.76	54.58±5.08	27.76±9.07^b
Muscle (n =6)	Aqueous	16.49±2.26	7.70±2.81^b	18.18±5.46	9.30±1.56^b
	Organic	44.55±8.06	43.43±11.19	39.74±10.78	59.27±6.95^b
	Pellet	38.95±7.41	48.85±12.63	42.06±9.84	31.41±7.23

Pretreated with POCA (30 mg/kg i.p.) 2 hr prior.

p=<0.05 for control vs POCA