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. 2012 Dec 12;32(50):18137–18149. doi: 10.1523/JNEUROSCI.3612-12.2012

Figure 2.

Figure 2.

Long-lasting hippocampal LTP is impaired in gravin GT mice. A, Input–output curves relating the amplitude of the presynaptic fiber volley to the initial slope of the corresponding fEPSP at various stimulus intensities was not altered in slices from gravin GT mice (one-way ANOVA, F(1,10) = 0.128, p = 0.727). B, Paired-pulse facilitation, a short-term form of synaptic plasticity, was not changed in slices from gravin GT mice (two-way repeated-measures ANOVA, F(4,44) = 0.415, p = 0.797). C, One-train LTP was unaltered in hippocampal slices from gravin GT mice (Kruskal–Wallis ANOVA, p > 0.05). D, Spaced four-train LTP is impaired in slices from gravin GT mice (Kruskal–Wallis ANOVA, p < 0.05). E, A long-lasting form of LTP induced by theta-burst stimulation (15 bursts) was impaired in slices from gravin GT mice (Kruskal–Wallis ANOVA, p < 0.05). F, Bath application with the β2-AR antagonist ICI 118551 (100 nm) impairs a long-lasting form of LTP induced by theta-burst stimulation (15 bursts) (Kruskal–Wallis ANOVA, p < 0.05). G, Massed four-train LTP, a PKA-independent form of long-lasting LTP was not impaired in slices from gravin GT mice (Kruskal–Wallis ANOVA, p > 0.05). H, Forskolin-mediated synaptic potentiation was not impaired in slices from gravin GT mice (Kruskal–Wallis ANOVA, p > 0.05). In all sample sweeps, black traces indicate baseline, and red traces were acquired at 1 h after tetanus (for C) or ∼2 h after stimulation (for D–H). Calibration: 2 mV, 10 ms. Error bars indicate SEM.