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. Author manuscript; available in PMC: 2012 Dec 31.
Published in final edited form as: Expert Opin Drug Metab Toxicol. 2009 Feb;5(2):109–130. doi: 10.1517/17425250902753212

Table 1.

Examples of PK–PD relationships of anti-cancer drugs [1,5].

Drug PK variable PD effect Ref.
5-fluorouracil AUC Neutropenia and thrombopenia [1,2]
CPT-11 Biliary index Diarrhea [3]
Carboplatin AUC Thrombocytopenia [4]
Cyclophosphamide AUC Toxicity and survival [5]

PD: Pharmacodynamics; PK: Pharmacokinetics.