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. 2012 Dec 10;123(1):215–223. doi: 10.1172/JCI62308

Figure 4. BAT transplantation increases circulating IL-6 and FGF21 concentrations, and Il6–/– mice do not show beneficial effects of BAT transplantation.

Figure 4

(A–E) Mice underwent sham operation or transplantation with 0.1 or 0.4 g BAT and were studied 12 weeks after transplantation. (A) Serum FGF21 and (B) FGF21 protein levels in endogenous BAT, (C) FGF21 protein levels in liver, (D) serum IL-6, (E) and Il6 measured by qPCR in endogenous BAT. Data are mean ± SEM. n = 6–17/group; *P < 0.05 compared with sham. **P < 0.01. ***P < 0.001. (F–H) Mice underwent sham operation or transplantation with 0.1 g BAT from Il6–/– or Il6+/+ mice. (F) GTT AUC, (G) serum leptin, and (H) body weight. Data are mean ± SEM. *P < 0.05 compared with sham and mice receiving 0.1 g Il6–/– BAT. n = 4–8/group.