Figure 2. Hepatic Xbp1s overexpression mimics the metabolic effects of refeeding.

RER (A) and food intake (B) of WT mice (n = 5 per group) during refeeding after a 24-hour fast. Time 0 represents 12 p.m. RER (C) and food intake (D) of WT and LIXs mice after Dox induction (n = 4 per group). Mice were switched to a Dox chow diet at 2 p.m. on day 3 in the metabolic cage. Time 0 represents 12 p.m. of day 4 (22 hours after induction). *P < 0.05.