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. 2012 Dec 21;123(1):455–468. doi: 10.1172/JCI62819

Figure 3. Hepatic Xbp1s overexpression triggers hypoglycemia.

Figure 3

(A) Hepatic glycogen staining from mice on Dox chow diet for 48 hours. Scale bars: 50 μm. (B) GLUT2 immunofluorescence staining. Scale bars: 50 μm. (CE) Mice (n = 3 per group) were fed Dox chow diet for 24–96 hours. Serum glucose levels (C), liver TG content (D), and serum free fatty acid levels (E) under fed or 6-hour fast conditions. *P < 0.05. (F) Serum glucose levels during a pyruvate tolerance test (n = 3 per group). *P < 0.05.