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. 2012 Dec 21;123(1):455–468. doi: 10.1172/JCI62819

Figure 7. GalE is a target gene of Xbp1s.

Figure 7

(A) A consensus binding site of Xbp1s is indicated on alignment of GalE promoters from mouse, rat, and human. (B) Luciferase assays for GalE promoter regulated by Xbp1s in HEK293T cells (n = 3–6 per group). (C) Deletion or mutation of the Xbp1s binding site reduces luciferase activity (n = 3 per group). *P < 0.05. (D) Xbp1s protein association with Gale promoter examined by ChIP assay using WT livers under condition of fasting, 2 hours refeeding, and 6 hours refeeding. Ctrl, control.