Figure 3. 901 normalizes early myelo-erythroid populations in Mx1-Cre;Nf1^flox/flox (Nf1) mice.

(A) Representative profiles of myeloid progenitors (MP) in the spleens of WT and Nf1 mice treated with vehicle or 901 for 12 weeks. (B) Total numbers of splenic myeloid progenitor cells in WT and Nf1 mice treated with 901 for 5 days or 12 weeks. (C) Total numbers of KLS cells in spleen and BM. In B and C, the error bars show SEM (n = 5–10 per group), and asterisks indicate significant differences between vehicle-and 901-treated Nf1 mice (*P < 0.05, **P < 0.01, ***P < 0.0001).