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. 2012 Dec 10;123(1):236–246. doi: 10.1172/JCI63679

Figure 5. Role of MyD88, IL-1R, and IL-18 in CaOx nephropathy.

Figure 5

(A) Oxalate deposition was similar in Myd88–/–, Il1r–/–, and Il18–/– mice, but plasma creatinine levels and BUN were not significantly increased, suggesting a protective role of these molecules in CaOX-induced renal damage. (B) PAS staining illustrated tubular necrosis. Original magnification, ×100. (C) Tubular injury score was determined by semiquantitative scoring, and renal neutrophil counts were determined by immunostaining and quantified per hpf. Data are means ± SEM from 5–6 mice per group. *P < 0.05, **P < 0.01, ***P < 0.001.