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. 2012 Dec 17;123(1):150–163. doi: 10.1172/JCI64946

Figure 4. miR-181a expression enhances Erk1/2, Akt, and Src signaling in breast cancer cells.

Figure 4

(A–F) 4T1 cells that harbored manipulated miR-181a activity as indicated were stimulated with TGF-β1 (5 ng/ml) for 30 minutes. Afterward, the phosphorylation and expression of Smad2/3, Erk1/2, Akt, and Src were measured by immunoblotting as indicated. Shown are representative images from 3 independent experiments. Scr, scrambled control vector; miArr, miArrest vector. Lanes in B, E, and F were run on the same gel, but were noncontiguous (white lines).