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. 2012 Dec 17;123(1):189–205. doi: 10.1172/JCI64993

Figure 3. Acriflavine blocks coculture-induced expression of CCL5, CCR5, CXCL10, and CXCR3.

Figure 3

BCCs, MSCs, or BCCs+MSCs were treated with 1 μM acriflavine (ACF) or 0.02% DMSO vehicle (Veh) and exposed to 20% or 1% O2 for 48 hours prior to RNA isolation. CXCL10 (A), CXCR3 (B), CCL5 (C), and CCR5 (D) mRNA levels were analyzed by RT-qPCR (mean ± SEM; n = 3). Levels were normalized to vehicle-treated BCCs at 20% O2. *P < 0.01 vs. 20% BCCs+MSCs vehicle; **P < 0.001 vs. 1% BCCs+MSCs vehicle, 1-way ANOVA.