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Ac2-26 binds to FPR1, which induces Src activation (Src p-Y418), resulting in the formation of a complex comprising active Rac1, p120 catenin, Vav2, and NOX1. ROS generated by NOX1 induces oxidative inactivation of PTEN and PTP-PEST, leading to increased phosphorylation of the focal adhesion proteins FAK and Pax, thereby promoting epithelial cell movement and wound repair.
