FIGURE 8.
Minimal photobleaching in vivo using microlensed spinning-disk confocal microscopy. A single optical section was imaged 1000 consecutive times in three colors—EGFP (green), ECFP (blue) propidium iodide (PI; red)—in an MMTV-PyMT;ACTB-ECFP;c-fms-EGFP mouse injected intraperitonally with PI to label dead cells. Images are shown at (A) exposure 1 and (A′) exposure 1000 Scale bar, 100 μm. (For color figure, see doi: 10.1101/pdb.top97 online at www.cshprotocols.org.)