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. 2012 Dec 31;6:337. doi: 10.3389/fnhum.2012.00337

Figure 5.

Figure 5

(A) Histogram of Z-values for the functional connectivity between visual cortex and activated regions from contrast [EO > EC] (block design experiment) during EC and EO. FC, Functional connectivity. *indicates p < 0.05 uncorrected. Compared with EC, FC between the visual and auditory cortices was significantly reduced during EO (t = 2.87, p = 0.01 uncorrected), as was FC between visual cortex and pACC (t = 2.46, p =0.024 uncorrected). (B) FC between the visual and auditory cortices during EC was positively correlated with the local-to-global ratio of GABAA receptor BPND in visual cortex (r = 0.564, p = 0.012 uncorrected); in contrast, during EO, the relationship becomes negative (r = −0.534, p = 0.018 uncorrected). (C) Difference (EC-EO) in FC between the visual and the auditory cortex was significantly correlated with local-to-global ratio of GABAA receptor BPND in the visual cortex [r = 0.667, p = 0.002 (p < 0.05, with Bonferroni correction)]. (D) Voxel-wise regression of local-to-global ratio of GABAA receptor BPND in the visual cortex ROI against whole-brain FC Z-value difference (EC-EO) (visual cortex ROI as seed region); significant clusters in bilateral auditory cortex are shown (p < 0.05, FWE corrected).