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. 2013 Jan;344(1):133–140. doi: 10.1124/jpet.112.198689

Fig. 4.

Fig. 4.

Administration of LY293558 (i.m.) protects against neuronal degeneration, 7 days after soman-induced SE. (A and B) Panoramic photomicrographs of Nissl-stained sections showing the brain regions from where the Fluoro-Jade C (FJC) photomicrographs shown in (C) were taken. (C) Representative photomicrographs of FJC-stained sections from the brain regions where neuronal degeneration was evaluated, for the SOMAN and the SOMAN+LY293558-treated groups. Total magnification is 100× . Scale bar is 50 μm. (D) Bar graph showing the median neuropathology score and interquartile range (n = 18 for the SOMAN group and n = 18 for the SOMAN+LY293558 group) for the amygdala (Amy), piriform cortex (Pir), entorhinal cortex (Ent), the CA1 and CA3 subfields of the ventral hippocampus, hilus, and neocortex (neo-Ctx). *P < 0.05, **P < 0.01, and ***P < 0.001 in comparison with the SOMAN group (Mann-Whitney U test).