. 2013 Jan;344(1):133–140. doi: 10.1124/jpet.112.198689

TABLE 1.

Efficacy of LY293558 (15 mg/kg) against soman-induced seizures and lethality, when administered along with atropine and HI-6, at 20 minutes after soman exposure

	SOMAN+ Atropine+ HI-6	SOMAN+ Atropine+ HI-6+ LY293558
Latency to SE (min)^a	9.5 ± 2	9.85 ± 0.7
Mortality rate^b	10/28 (35.7)	0/18 (0)
Seizure control^c	0/28	18/18
Latency to stop SE (min)^d	N/A	36.9 ± 3.2

^{^a}

Data are mean ± S.E.M. and indicate the time elapsed between injection of soman and initiation of generalized seizures.

^{^b}

Data are number (%) of animals that died out of the total sample size.

^{^c}

Data are number of animals in which seizures were controlled by the administration of atropine+HI-6 or atropine+HI-6+LY293558 out of the total sample size.

^{^d}

Data are mean ± S.E.M. and indicate the time elapsed between injection of LY293558 and the suppression of behavioral seizures below stage 2.