TABLE 2.
Plasma and brain concentrations of LY293558 after i.m. administration at the dose of 15 mg/kg
Shown are the number of animals used at different time points, and the group mean and SD of the LY293558 concentrations. The ratio of the brain over plasma concentrations is shown on the last column.
| Time (hours) | Plasma ng/ml |
Brain ng/g |
Ratio B/P | ||||
|---|---|---|---|---|---|---|---|
| Number of Animals | Mean | SD | Number of Animals | Mean | SD | ||
| 0.25 | 6 | 18,435.0 | 1,472.9 | 3 | 318.7 | 23.9 | 0.017 |
| 0.5 | 6 | 8,453.3 | 3,341.5 | 3 | 125.3 | 24.6 | 0.015 |
| 1 | 6 | 1,758.3 | 570.7 | 6 | 119.8 | 76.1 | 0.068 |
| 1.5 | 3 | 609.7 | 61.1 | 3 | 36.5 | 3.5 | 0.060 |
| 2 | 3 | 204.7 | 27.8 | ||||
| 4 | 3 | 44.4 | 4.4 | ||||
| 6 | 3 | 40.0 | 6.2 | ||||
| 8 | 3 | 9.0 | 2.7 | <LLOQ | |||
| 24 | 3 | <LLOQ | |||||
| 48 | 3 | <LLOQ | <LLOQ | ||||