TABLE 1.
Firing rates of VTA neurons: effects of inhibitors and quinpirole
| Figures | Change by inhibitors | Pre-quinpirole or DA baseline FR (Hz) | Percentage change by DA or quinpirole at 5 min |
|---|---|---|---|
| Figure 1 | |||
| Control (no inhibitor) | — | 2.07 ± 0.17 | −72.78 ± 4.83 |
| β-ARK1 inhibitor | −2.71 ± 3.25 | 2.45 ± 0.27 | −64.47 ± 3.42 |
| Dynasore | −2.51 ± 2.49 | 2.35 ± 0.24 | −62.99 ± 3.0 |
| Figure 2 | |||
| Control (no inhibitor) | — | 2.55 ± 0.34 | −68.27 ± 4.94 |
| Neurotensin (10 nM) | — | 3.63 ± 0.38 | −65.5 ± 4.16 |
| Neurotensin (5 nM) | — | 3.15 ± 0.58 | −61.65 ± 6.2 |
| β-ARK1 inhibitor | −7.75 ± 3.53 | 1.8 ± 0.45 | −68.21 ± 6.85 |
| Gö6976 | 0.88 ± 3.0 | 1.38 ± 0.22 | −64.54 ± 6.24 |
| Dynasore | −6.79 ± 3.9 | 1.75 ± 0.15 | −64.31 ± 6.35 |
| Figure 3 | |||
| Serotonin | — | 2.53 ± 0.21 | −64.02 ± 5.38 |
| β-ARK1 inhibitor | −2.95 ± 1.94 | 2.23 ± 0.32 | −73.68 ± 5.93 |
| Gö6976 | −9.04 ± 3.63 | 1.41 ± 0.28 | −58.3 ± 2.75 |
| Dynasore | −2.03 ± 2.63 | 2.59 ± 0.3 | −62.26 ± 6.57 |
β-ARK1 inhibitor, methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate; DA, dopamine; FR, firing rate; Gö6976 (5,6,7,13-tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4c]carbozole-12-propanenitrile); VTA, ventral tegmental area.