Fig. 1.

Antinociceptive effect of various α7 nicotinic compounds in the tail-flick and hot-plate tests after acute administration in mice. (A) Effects of nicotine (2.5 mg/kg s.c.), PHA543613 (8 mg/kg s.c.), PNU-120596 (4 and 8 mg/kg i.p.), and NS1738 (10 and 30 mg/kg i.p.) in the tail-flick test. Mice were treated s.c. with nicotine 5 minutes before testing. The other treatment groups received PHA-543613, PNU-120596, or NS1738 15 minutes before the tail-flick test. (B) Effects of nicotine, PHA-543613, PNU-120596, and NS1738 in the hot plate test. Mice were treated using the same doses and pretreatment times as for the tail-flick test. Each group represents the mean ± S.E. of six to eight mice. *P < 0.05 versus vehicle. Nic, nicotine; NS, NS1738; PNU, PNU-120596; Veh, vehicle.