Fig. 2.

Effects of α7 type I PAM NS1738 in the mouse formalin test. Time course of the effects of NS1738 during phase 1 (A) and phase 2 (B) in the formalin test after i.p. administration. Mice were treated with either vehicle (Veh) or NS1738 (10 mg/kg, i.p) at different times after injection (15 minutes, 1 hour, and 3 hours) before intraplantar formalin injection in the right paw. The dose-response relationship for NS1738 was established in mice 15 minutes after i.p. injection of various doses of drugs during phase 1 (C) and phase 2 (D) of the formalin test. Each symbol represents the mean ± S.E.M. of total time spent licking for 8–10 mice/group. *P < 0.05 versus vehicle.