Fig. 4.

Effects of α7 agonist PHA-543613 in the mouse formalin test. Time course of the effects of PHA-543613 during phase 1 (A) and phase 2 (B) in the formalin test after s.c. administration. Mice were treated with either vehicle (Veh) or PHA-543613 (6 mg/kg s.c.) 15 and 60 minutes after injection before intraplantar formalin injection in the right paw. The dose-response relationship for PHA-543613 was then established in mice 15 minutes after s.c. injection of various doses of drugs during phase 1 (C) and phase 2 (D) of the formalin test. Each symbol represents the mean ± S.E.M. of total time spent licking for 8–10 mice/group. *P < 0.05 versus vehicle.